Circular Leter Merger Proposal PT Dankos Laboratories Tbk. and PT Enseval into PT KALBE FARMA Tbk.

In relation to the Merger plan, the Board of Directors of the Merger Participants hereby present this Merger Proposal for information to shareholders of each of the Merger Participants, creditors of each of the Merger Participants as well as other relevant parties to the Merger in order to obtain approval from the EGMOS of each Merger Participant to be held on 29 November 2005.


For more information regarding this merger plan, you can click the address below: http://www.kalbefarma.com/files/investor/CircularKalbe.pdf (510 kb)

Promag Double Action, coming soon !!!

As the leader of gastric medication market share in Indonesia (80%), Promag as one of PT Kalbe Farma Tbk brands, does not just sit back, but keep on developing new innovations. Last but not least, PT Kalbe Farma (JSX: KLBF) will launch new variant of Promag, intended for its premium segment.

Promag Double Action works in two-way approach in gastric management. It is the first OTC combine drug in Indonesia, Antacid and Acid Blocker.

In the picture taken after the press conference, from left to right: Rully Prasetyanto (Product Executive), Sinteisa Sunarjo (Group Product Manager), Eliana Taufik (Internist), Mayong Laksono (Moderator), Djoni Hartono (Assistant Director OTC).

According to Eliana, an internist, gastric pains in medical terms is called Dyspepsia Syndrome. Its symptoms are: pain, nausea and even vomiting.


The causes can be divided into two:

1. Organic such as: the presence of stomach ulcer, etc
2. Functional such as: the increase of stomach acid and stomach sensitivity even though the stomach acid remains unchanged, etc.

The gastric pain management itself starts from the diet, a change in lifestyle up to the consumption of medications.

Up to the moment, the circulating Over The Counter drugs are antacids. The function of antacids is to neutralize stomach acid.


Promag Double Action

Promag Double Action works 2 ways, it neutralises and slows down the production of stomach acid or Antagonist H2.


The Submarine Analogy

According to Djoni Hartono, Assistant Director OTC PT Kalbe Farma Tbk, for an easier understanding, gastric pain can be compared with a leaking submarine. If the leakage is small, then it is enough to use a mop to clean the affected area just like using antacids, but if the leakage is getting larger then it needs to be patched, otherwise the submarine will be filled with water. Hence is the purpose of a medication that can suppress the production of stomach acid. The stomach acid suppressant works slowly (therefore it needs to be combined with the antacid that works instantly) but it can work up until 12 hours.

2 Chewable Tablets a Day
Because of Promag’s Double Action long working period, 2 chewable tablets in a day is enough. Unlike a couple of antacid tablets, that have to be consumed 3-4 times day, when the symptoms are quite bad.

BAHASA INDONESIA

CEO of Kalbe Farma received "The Innovation Indonesia Business Leader Award 2005"

Just recently, Mr. Johannes Setijono as CEO of Kalbefarma received "The Innovation Indonesia Business Leader Award 2005" carried out by CNBC Asia and Bank Mandiri.
The event itself was held on September 23rd, 2005.

The judging and selection process was done to 200 Indonesia Business Leaders of 2005, by a line of judges who are highly competent in their fields. It was presided by University of Chicago Graduate Business School as well as some business leaders in Asia.

At the same time, Mr. Budi Dhrama from EPM (Enseval Putra Megatrading) also received an award as one of the finalists in Top 8 Indonesia Business Leader 2005.

About this award

Another award news:
- Kalbe Snatched the Forbes Global Award
- Kalbe Farma is One of the 2003 Indonesia Business Award Winners


BAHASA INDONESIA

Kalbe Farma launched a drug for Endometriosis

Do you suffer from menstrual cramps? Now you can be relieved since PT Kalbe Farma (JSX: KLBF) has marketed a generic product meant for those who have Endometriosis. PT Kalbe Farma’s introduction of Endrolin (product brand) to various print and electronic media was done today in Jakarta. In the picture dr. Antonio Bouzad (a manufacturer from Argentina) is giving Madam Irawati Setiadi (Kalbe Farma) a symbol of Endrolin.

Period Pains
According to dr. Indra Anwar, an Ob-Gyn Specialist from RS Bunda, Menstrual Cramps or Dysmenorrhea is a menstruation disorder suffered by many women. One cause of Dysmenorrhea is Endometriosis or a growth (non-cancer) of endometrium outside the womb. Endometriosis lesion can be found in the Ovaries, Fallopian Tubes and Pelvic Cavity. It can also be found at the Ileum, Colon, Bladder even the Lungs, Spine as well as the Brain. As a result, during a time of menstruation, the areas that have lesions on them will also suffer from hemorrhage.


Endometriosis Treatment
Various ways have been done to treat Endometriosis, some of them include:

1. By giving painkillers
2. By giving medications for the cause
3. Surgery
4. Complementary Therapy

Endrolin / Leuprorelin
Endrolin which contains 3.75mg of Leuprolide Acetate works by depressing the production of Esterogen (female hormone). The hypo-estrogenic condition caused the Endometrium network in and outside the uterus to shrink.

According to an investigation, the hypo-estrogenic condition may decrease symptoms, such as Menstrual Cramps, Abdominal pain and intercourse pain, etc which usually appear because of Endometriosis.

Along with the information acquired from the Press Conference, Endrolin offers women the freedom from conditions caused by Endometriosis including Menstrual Cramps. It also has easy and convenient dosing methods, reversible and light side effects, simple dosage and inexpensive.

BAHASA INDONESIA

Innogene Kalbiotech, a subsidiary of PT Kalbe Farma to penetrate global market

Not only does it wasn’t to be the best in the country but (at the moment "JSX: KLBF" have become the biggest Pharmaceutical company in the Jakarta Stock Exchange), T Kalbe Farma wishes to penetrate the global market, by inventing new products (internationally patented). Hence Indonesia can be proud of the original pharmaceutical drugs produced by PT Kalbe Farma. Through Innogene Kalbiotech, Kalbe Farma will become a drug development companywhich focuses on clinical development. Such is the resolution from the Press Conference held at PT Kalbe Farma’s Marketing Office on Friday, July 29th, 2005.

Innogene Kalbiotech
Innogene Kalbiotech which stands for Innovation Generator Kalbe Farma Biotechnology is a subsidiary of Pt Kalbe Farma, it started on July 8th, 2003. Based on superior science and technology, the company strive to be the best in Pharmaceutical business and invent top products which can penetrate the markets in developed countries. According to Dr Rikrik Ilyas, as Director of Innogene Kalbiotech, besides the drug developments, the company also creates innovative diagnostic equipment which requires scientific and clinical developments in Global Market. From the aspect of class therapy, Innogene specializes itself in the developments of Oncology, Critical Care, Vaccines (therapeutical & preventive) and diagnostics.

Products
Some available Biogeneric products:

1. Hemapo , for the therapy of anemia in dialysis patients caused by kidney failure
2. Kalferon, for chronic Hepatitis B and C patients
3. Fimalbumin, for hypoproteinemia management, with or without edema
4. Fimakinase, for acute miokard infarct therapy, vena cava inferior thrombosis, acute massive lung embolism , acute thrombosis and artery embolism
5. BTXA , for the therapy of strabismus and blepharospasm caused by dystonia
6. Mediflex, a break-through formula to ease topical transdermal arthritis pain
7. Leucogen, a product to ease fever, which is still in evaluation process for patients with non-myeloid under chemotherapy.

BAHASA INDONESIA