Palonosetron (Paloxi) , a new anti-emetic drug from Kalbe Farma

Symposium “The 1st Tulip Oncology Summit 2006” with the topic of “From Basic to Clinic: Empowering Translational Research” was held at Sheraton Hotel Yogyakarta on April 15-16, 2006. There were around 400 participants who consist of oncologists, general physicians and medical students.
There were several interesting topics delivered, such as the new medicine Palonosetron introduced by Dr. Zakitman Jack, SpPD-HKOM and sponsored by PT. Kalbe Farma with the topic of “A Novel 5-HT3 Receptor Antagonist for Chemotherapy Induced Nausea and Vomiting”.

Hereby explained that nausea and vomiting from chemotherapy mostly is caused by the release of serotonin on the gastrointestinal mucosa, therefore the standard treatment for nausea and vomiting is based upon the serotonin antagonist. The anti-emetics from the class of serotonin antagonist which are currently available on the market do not have optimal effectivity. Therefore, PT Kalbe Farma marketed the most recent anti-emetic of serotonin antagonist class called Palonosetron. There are several advantages of Palonosetron from its pharmacological side, which has longer half life (up to 40 hours) therefore only needed once on the first day of chemotherapy with the effectivity up to days 5 and 6. Thus this can prevent the occurrence of nausea and vomiting acutely for the first 24 hours after chemotherapy up to 120 hours afterwards.
On the clinical trial phase III, Palonosetron 0.25mg compared with other serotonin antagonist such as Ondansetron and Dolasetron on the standard dose, Palonosetron has similar effectivity equal to those two drugs to prevent the side effects of nausea and vomiting within the first 24 hours. However, it is more effective after the first 24 hours of chemotherapy up to day 5 preventing the moderate and high emetogenic effect of chemotherapy.
In Indonesia, Palonosetron will launch soon with brand name: Paloxi

Media Workshop & Testimonial Book Launch PROMAG MULIA

Welfare deterioration of lower socio-economic status community and the success of pioneer PROMAG MULIA Program (2005) underlie PT Kalbe Farma Tbk to keep instituting amateur entrepreneurship trainings in 6 cities (Jakarta, Bandung, Surabaya, Makassar, Medan and Lampung). These trainings provide professional entrepreneurship knowledge of the ManagementQolbuTrainingCenter whose chair is KH Abdullah Gymnastiar from Darul Tauhid Bandung. This is the news of press release together with the Testimonial Book Launch titled “Jangan Jadi Pengusaha Bila Tidak Berani Memulai (Don’t Be An Entrepreneur If You Don’t Dare To Start)” in JakartaApril 13, 2006.
(picture: Mr Johannes Setijono with Aa Gym)

The pioneer PROMAG MULIA Program (Membangun Usaha Lewat Ilmu dan Ahklak/Establishing Business With Knowledge and Morality) attracted 20 participants from 5 cities. This exhibited the enthusiasm and expertise, furthermore motivating a book to be written, titled “Jangan Jadi Pengusaha Bila Tidak Berani Memulai” (Don’t Be An Entrepreneur If You Don’t Dare To Start). This book is a consolidation of experiences and tips to be shared by the participants for the community. This book can be obtained at the bookstores which sell Aa Gym books.

Mr. Johannes Setijono as the President Director of PT Kalbe Farma Tbk stated that: “We cannot imagine how many amateur entrepreneurs who try to build their own business independently and how big their success contributes to the Indonesian economy and welfare. Therefore, PROMAG MULIA intends to help to expand their businesses until they become durable and competitive professional entrepreneurs. With the provided assistance given, hopefully the number of entrepreneurs will be increasing year-by-year”.

This program is aimed for amateur entrepreneurs from B, C and D class with the age range of 18-30 years old, healthy, have their own business, passed the test and interview which were held in several cities.

KH Abdullah Gymnastiar (Aa Gym) as the chair of “Management QolbuTrainingCenter” stated that “Success is not something for granted but have to be earned with enthusiasm. Only entrepreneurs with good morality will be a great leader, and if there are more people with good morality then this nation will be a great nation”.

The training packages provided by PROMAG MULIA program was compiled by MQ. It is very concentrated so it requires prime health of the participants. In order to understand the allocated program, at the event of April 13, 2006, several journalists were invited to participate on the events which are held frequently by PROMAG MULIA. After this event, there were books distribution with the autograph of Mr. Johannes and Aa Gym.

PIRA Indonesian Award 2006
Recently PROMAG MULIA program won International Public Relation Association / PIRA-Indonesian Award 2006 as the best CSR Programme (Corporate Social Responsibility Programme).

- Official website, http://www.promagmulia.com/

BAHASA